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KMID : 0361020070500040335
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Korean Journal of Otolaryngology - Head and Neck Surgery
2007 Volume.50 No. 4 p.335 ~ p.340
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The Detection of Epstein-Barr Virus and Expression of bcl-2 and p53 Proteins in the Extranodal Malignant Lymphoma of the Head and Neck
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Bae Chang-Hoon
Song Si-Youn
Kim Yong-Dae
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Abstract
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Background & Objectives: Although the cause of the malignant lymphoma has not been understood entirely, viruses and oncogenes have been implicated as probable causative factors. Particularly, Epstein-Barr virus (EBV), the over-expression of bcl-2 and the mutant p53 seem to be closely related to lymphomatogenesis. The purpose of this study was to investigate the relationship between EBV, bcl-2 and p53 proteins in the development of human extranodal malignant lymphoma in the head and neck.
Subjects & Methods: Specimens were obtained from 40 patients diagnosed as the extranodal malignant lymphoma in the head and neck region. Paraffin-embedded tumor tissues were analyzed by in situ hybridization for Epstein-Barr virus encoded RNA(EBER) and by immunohistochemical technique for bcl-2 and p53 proteins.
Results: In EBER and bcl-2 protein-positive group, there were no significant differences in the pathologic types. However, the angiocentric lymphoma type (85.7%) and the peripheral T cell lymphoma unspecified large cell type (83.3%) were identified significantly in the p53 protein positive group (p<0.05). Expression rate of EBER, bcl-2 and p53 protein were 50%, 42.5% and 53.5%, respectively. In the EBER-positive group (20 cases), bcl-2 protein was detected in 9 cases (45.0%) and p53 protein in 11 cases (55.0%). In bcl-2 protein-positive group (17 case), p53 protein was detected in 9 cases (52.9%). There were no significant difference among these data (p>0.05).
Conclusion: These results suggest that EBV, bcl-2 and p53 protein play a role in the tumorigenesis of the human extranodal malignant lymphoma, independently.
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KEYWORD
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Lymphoma, Epstein-Barr Virus, bcl-2, p53
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